Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC5762319 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Wang Zhen Z Wang Wei W Huang Kangrong K Wang Yueling Y Li Jing J Yang Xinyuan X
Oncotarget 20171130 67
MicroRNAs (miRNAs) are small non-coding RNAs composed of 18-25 nucleotides that regulate the expression of approximately 30% of human protein coding genes. Dysregulation of miRNAs plays a pivotal role in the initiation and progression of malignancies. Our study has shown that microRNA-34a (miR-34a) was upregulated in human endometrial cancer stem cells (ECSCs). However, it is unknown how miR-34a regulates endometrial cancer itself. Here, we report that miR-34a directly and functionally targeted ...[more]