Novel Cancer Stem Marker and Its Applicability for Grading Primary Human Gliomas.
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ABSTRACT:
SUBMITTER: Dolgova EV
PROVIDER: S-EPMC5789816 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Publications
Novel Cancer Stem Marker and Its Applicability for Grading Primary Human Gliomas.
Dolgova Evgeniya V EV Mishinov Sergey V SV Proskurina Anastasiya S AS Potter Ekaterina A EA Efremov Yaroslav R YR Bayborodin Sergey I SI Tyrinova Tamara V TV Stupak Vyacheslav V VV Ostatin Alexandr A AA Chernykh Elena R ER Bogachev Sergey S SS
Technology in cancer research & treatment 20180101
Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA. Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fluorescently labeled DNA probe. Of these, using samples from 3 patients, 66% to 100% cells are also positive for CD133, a well-established surface marker of tumor-initiating glioma s ...[more]
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