Ontology highlight
ABSTRACT:
SUBMITTER: Ji S
PROVIDER: S-EPMC5796521 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Ji Shaofei S Shao Hongzhao H Han Qiyuan Q Seiler Christopher L CL Tretyakova Natalia Y NY
Angewandte Chemie (International ed. in English) 20171006 45
5-Formylcytosine (5fC) is an endogenous DNA modification frequently found within regulatory elements of mammalian genes. Although 5fC is an oxidation product of 5-methylcytosine (5mC), the two epigenetic marks show distinct genome-wide distributions and protein affinities, suggesting that they perform different functions in epigenetic signaling. A unique feature of 5fC is the presence of a potentially reactive aldehyde group in its structure. Herein, we show that 5fC bases in DNA readily form Sc ...[more]