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Quantitative Magnetization Transfer in Monitoring Glioblastoma (GBM) Response to Therapy.


ABSTRACT: Quantitative magnetization transfer (qMT) was used as a biomarker to monitor glioblastoma (GBM) response to chemo-radiation and identify the earliest time-point qMT could differentiate progressors from non-progressors. Nineteen GBM patients were recruited and MRI-scanned before (Day0), two weeks (Day14), and four weeks (Day28) into the treatment, and one month after the end of the treatment (Day70). Comprehensive qMT data was acquired, and a two-pool MT model was fit to the data. Response was determined at 3-8 months following the end of chemo-radiation. The amount of magnetization transfer ([Formula: see text]) was significantly lower in GBM compared to normal appearing white matter (p?

SUBMITTER: Mehrabian H 

PROVIDER: S-EPMC5802834 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Quantitative Magnetization Transfer in Monitoring Glioblastoma (GBM) Response to Therapy.

Mehrabian Hatef H   Myrehaug Sten S   Soliman Hany H   Sahgal Arjun A   Stanisz Greg J GJ  

Scientific reports 20180206 1


Quantitative magnetization transfer (qMT) was used as a biomarker to monitor glioblastoma (GBM) response to chemo-radiation and identify the earliest time-point qMT could differentiate progressors from non-progressors. Nineteen GBM patients were recruited and MRI-scanned before (Day<sub>0</sub>), two weeks (Day<sub>14</sub>), and four weeks (Day<sub>28</sub>) into the treatment, and one month after the end of the treatment (Day<sub>70</sub>). Comprehensive qMT data was acquired, and a two-pool M  ...[more]

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