Ontology highlight
ABSTRACT:
SUBMITTER: Nakatake R
PROVIDER: S-EPMC5834814 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Nakatake Richi R Kaibori Masaki M Nakamura Yusuke Y Tanaka Yoshito Y Matushima Hideyuki H Okumura Tadayoshi T Murakami Takashi T Ino Yasushi Y Todo Tomoki T Kon Masanori M
Cancer science 20180214 3
Multimodality therapies are used to manage patients with hepatocellular carcinoma (HCC), although advanced HCC is incurable. Oncolytic virus therapy is probably the next major breakthrough in cancer treatment. The third-generation oncolytic herpes simplex virus type 1 (HSV-1) T-01 kills tumor cells without damaging the surrounding normal tissues. Here we investigated the antitumor effects of T-01 on HCC and the host's immune response to HCC cells. The cytopathic activities of T-01 were tested in ...[more]