Ontology highlight
ABSTRACT:
SUBMITTER: Novo CL
PROVIDER: S-EPMC5863031 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Novo Clara Lopes CL Javierre Biola-Maria BM Cairns Jonathan J Segonds-Pichon Anne A Wingett Steven W SW Freire-Pritchett Paula P Furlan-Magaril Mayra M Schoenfelder Stefan S Fraser Peter P Rugg-Gunn Peter J PJ
Cell reports 20180301 10
Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active chromatin, and they are commonly assigned to target promoters using computational predictions. How promoter-SE interactions change upon cell state transitions, and whether transcription factors maintain SE interactions, have not been reported. Here, we used pro ...[more]