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Journey from oncologist to cancer survivor and patient advocate in the era of precision medicine.

ABSTRACT: In 2013, the American Association for Cancer Research (AACR) introduced the "Precision Medicine Series" of symposia. The goal of these conferences is to "highlight the incredible technology and advances in cancer research that together are enabling treatments that are precisely targeted to the unique molecular and genetic characteristics of an individual's cancer." This new series of AACR conferences reflects how patient treatment has evolved and continues to progress toward personalized treatments/medicine. It was in May of 2013 that I was diagnosed with a rare form of bladder cancer, plasmacytoid variant, for which survival statistics were grim, and the only genomic information available was the frequent somatic CDH1 loss-of-function mutation consistent with aggressive clinical behavior. The CDH1 gene encodes for E-cadherin, which plays a role in cell-cell adhesions and acts as a tumor suppressor when expressed normally. This information was subsequently published, but not until April 2016 (Al-Ahmadie et al. 2017. Nat Genet48: 356-358). At the time, I was a practicing medical oncologist and, ironically, urologic cancers had been my area of interest, dating back to my fellowship at Memorial Sloan Kettering Cancer Center (MSKCC) in 1981. I decided to return to MSKCC for treatment based on their experience with rare urologic cancers as well as my own personal connection.

SUBMITTER: Needles BM

PROVIDER: S-EPMC5880268 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other

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Journey from oncologist to cancer survivor and patient advocate in the era of precision medicine.

Needles Burton M BM

Cold Spring Harbor molecular case studies 20180402 2

In 2013, the American Association for Cancer Research (AACR) introduced the "Precision Medicine Series" of symposia. The goal of these conferences is to "highlight the incredible technology and advances in cancer research that together are enabling treatments that are precisely targeted to the unique molecular and genetic characteristics of an individual's cancer." This new series of AACR conferences reflects how patient treatment has evolved and continues to progress toward personalized treatme ...[more]

PMID: 29610393

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Project description:Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer. Currently, all prostate cancer patients receive essentially the same treatment, and there is a need for clinically applicable technologies to provide predictive biomarkers toward personalized therapies. Genomic analyses of tumors are used for clinical applications, but with a paucity of obvious driver mutations in metastatic castration-resistant prostate cancer, other applications, such as phosphoproteomics, may complement this approach. Immunohistochemistry and reverse phase protein arrays are limited by the availability of reliable antibodies and evaluates a preselected number of targets. Mass spectrometry-based phosphoproteomics has been used to profile tumors consisting of thousands of phosphopeptides from individual patients after surgical resection or at autopsy. However, this approach is time consuming, and while a large number of candidate phosphopeptides are obtained for evaluation, limitations are reduced reproducibility, sensitivity, and precision. Targeted mass spectrometry can help eliminate these limitations and is more cost effective and less time consuming making it a practical platform for future clinical testing. In this review, we discuss the use of phosphoproteomics in prostate cancer and other clinical cancer tissues for target identification, hypothesis testing, and possible patient stratification. We highlight the majority of studies that have used phosphoproteomics in prostate cancer tissues and cell lines and propose ways forward to apply this approach in basic and clinical research. Overall, the implementation of phosphoproteomics via targeted mass spectrometry has tremendous potential to aid in the development of more rational, personalized therapies that will result in increased survival and quality of life enhancement in patients suffering from metastatic castration-resistant prostate cancer.

Dataset Information

Journey from oncologist to cancer survivor and patient advocate in the era of precision medicine.

Publications

Journey from oncologist to cancer survivor and patient advocate in the era of precision medicine.

Similar Datasets

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