Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5882886 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Liu Yang Y Pejchinovski Martin M Wang Xueqi X Fu Xuebin X Castelletti Deborah D Watnick Terry J TJ Arcaro Alexandre A Siwy Justyna J Mullen William W Mischak Harald H Serra Andreas L AL
Scientific reports 20180403 1
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in animal models, but randomized controlled trials failed to prove efficacy of mTOR inhibitor treatment. Here, we demonstrate that treatment with mTOR inhibitors result in the removal of negative feedback loops and up-regulates pro-proliferative phosphat ...[more]