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Morphological adaptation of sheep's rumen epithelium to high-grain diet entails alteration in the expression of genes involved in cell cycle regulation, cell proliferation and apoptosis.


ABSTRACT: The objectives of this study were to characterize changes in the relative mRNA expression of candidate genes and proteins involved in cell cycle regulation, cell proliferation and apoptosis in the ruminal epithelium (RE) of sheep during high-grain (HG) diet adaptation.Twenty sheep were assigned to four groups with five animals each. These animals were assigned to different periods of HG diet (containing 40% forage and 60% concentrate mix) feeding. The HG groups received an HG diet for 7 (G7, n?=?5), 14 (G14, n?=?5) and 28 d (G28, n?=?5), respectively. In contrast, the control group (CON, n?=?5) was fed the forage-based diet for 28 d. The results showed that HG feeding linearly decreased (P?

SUBMITTER: Xu L 

PROVIDER: S-EPMC5901869 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Morphological adaptation of sheep's rumen epithelium to high-grain diet entails alteration in the expression of genes involved in cell cycle regulation, cell proliferation and apoptosis.

Xu Lei L   Wang Yue Y   Liu Junhua J   Zhu Weiyun W   Mao Shengyong S  

Journal of animal science and biotechnology 20180416


<h4>Background</h4>The objectives of this study were to characterize changes in the relative mRNA expression of candidate genes and proteins involved in cell cycle regulation, cell proliferation and apoptosis in the ruminal epithelium (RE) of sheep during high-grain (HG) diet adaptation.<h4>Results</h4>Twenty sheep were assigned to four groups with five animals each. These animals were assigned to different periods of HG diet (containing 40% forage and 60% concentrate mix) feeding. The HG groups  ...[more]

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