Ontology highlight
ABSTRACT:
SUBMITTER: Gregersen LH
PROVIDER: S-EPMC5929563 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Trends in biochemical sciences 20180501 5
In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. Over the past few years, a number of new results have shed light on this intriguing DNA damage response at the structural, biochemical, cell biological, and systems biolo ...[more]