Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.
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ABSTRACT:
SUBMITTER: Sheahan AV
PROVIDER: S-EPMC5940404 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
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Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.
Sheahan Anjali V AV Biankin Andrew V AV Parish Christopher R CR Khachigian Levon M LM
Oncotarget 20180420 30
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with unresectable (locally advanced or metastatic) tumors. We discuss a range of studies that employed FOLFIRINOX, the gemcitabine + nab-paclitaxel combination and studies that used molecularly-targeted therapy. Major areas of focus have been dual targeti ...[more]
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