Ontology highlight
ABSTRACT:
SUBMITTER: Dennis ASM
PROVIDER: S-EPMC5995868 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Dennis Adelaide S M ASM Rosling James E O JEO Lehane Adele M AM Kirk Kiaran K
Scientific reports 20180611 1
Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture's 'Pathogen Box' were screened for their effect on a range of physiological parameters in asexual blood-stage malaria (Plasmodium falciparum) parasites. Eleven of these compounds were found to perturb parasite Na<sup>+</sup>, pH and volume in a manner consistent with inhibition of the putative Na<sup>+</sup> efflux P-type ATPase PfATP4. All eleven compounds fell within the subset of 125 compounds i ...[more]