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A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles.


ABSTRACT: A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.

SUBMITTER: Campos JF 

PROVIDER: S-EPMC6017854 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles.

Campos Joana F JF   Loubidi Mohammed M   Scherrmann Marie-Christine MC   Berteina-Raboin Sabine S  

Molecules (Basel, Switzerland) 20180318 3


A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes. ...[more]

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