Rac1 activation links tau hyperphosphorylation and A? dysmetabolism in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Borin M
PROVIDER: S-EPMC6045891 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Publications
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Borin Mirta M Saraceno Claudia C Catania Marcella M Lorenzetto Erika E Pontelli Valeria V Paterlini Anna A Fostinelli Silvia S Avesani Anna A Di Fede Giuseppe G Zanusso Gianluigi G Benussi Luisa L Binetti Giuliano G Zorzan Simone S Ghidoni Roberta R Buffelli Mario M Bolognin Silvia S
Acta neuropathologica communications 20180713 1
One of the earliest pathological features characterizing Alzheimer's disease (AD) is the loss of dendritic spines. Among the many factors potentially mediating this loss of neuronal connectivity, the contribution of Rho-GTPases is of particular interest. This family of proteins has been known for years as a key regulator of actin cytoskeleton remodeling. More recent insights have indicated how its complex signaling might be triggered also in pathological conditions. Here, we showed that the Rho- ...[more]
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