Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6071786 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Zhang Yuan Y Damu Guri L V GLV Cui Sheng-Feng SF Mi Jia-Li JL Tangadanchu Vijai Kumar Reddy VKR Zhou Cheng-He CH
MedChemComm 20170615 8
A series of triazoles as miconazole analogues was designed, synthesized and characterized by IR, NMR, MS and HRMS. All the newly prepared compounds were screened for their antifungal activities against five kinds of fungi. The bioactive assay showed that most of the synthesized compounds exhibited good or even stronger antifungal activities in comparison with the reference drugs miconazole and fluconazole. In particular, the 3,4-dichlorobenzyl derivative <b>5b</b> showed a comparable or superior ...[more]