Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi M
PROVIDER: S-EPMC6131399 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Kobayashi Masae M Khalil Hassan A HA Lei Nan Ye NY Wang Qianqian Q Wang Ke K Wu Benjamin M BM Dunn James C Y JCY
Scientific reports 20180910 1
Oriented smooth muscle layers in the intestine contract rhythmically due to the action of interstitial cells of Cajal (ICC) that serve as pacemakers of the intestine. Disruption of ICC networks has been reported in various intestinal motility disorders, which limit the quality and expectancy of life. A significant challenge in intestinal smooth muscle engineering is the rapid loss of function in cultured ICC and smooth muscle cells (SMC). Here we demonstrate a novel approach to maintain the func ...[more]