Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6151529 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Wang Xinran X Hao Lijuan L Xu Xuanqi X Li Wei W Liu Chunchi C Zhao Dongmei D Cheng Maosheng M
Molecules (Basel, Switzerland) 20171003 10
N,N-Substituted amine derivatives were designed by utilizing a bioisosterism strategy. Consequently, twenty-two compounds were synthesized and evaluated for their inhibitory activity against CETP. Structure-activity relationship (SAR) studies indicate that hydrophilic groups at the 2-position of the tetrazole and 3,5-bistrifluoromethyl groups on the benzene ring provide important contributions to the potency. Among these compounds, compound 17 exhibited excellent CETP inhibitory activity (IC<sub ...[more]