Ontology highlight
ABSTRACT:
SUBMITTER: Qing LS
PROVIDER: S-EPMC6152088 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Qing Lin-Sen LS Peng Shu-Lin SL Liang Jian J Ding Li-Sheng LS
Molecules (Basel, Switzerland) 20170731 8
There is an urgent need for a water-soluble derivative of astragaloside IV for drug R&D. In the present study, a remarkably simple method for the preparation of such a water-soluble derivative of astragaloside IV has been developed. This protocol involves oxidative 2,2,6,6-tetramethylpiperidine-1-oxyl free radical (TEMPO)-mediated transformation of astragaloside IV to its carboxylic acid derivative, which is a new compound named astragalosidic acid. The structure of astragalosidic acid was eluci ...[more]