Ontology highlight
ABSTRACT:
SUBMITTER: Will-Orrego A
PROVIDER: S-EPMC6152860 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Will-Orrego Adrian A Qiu Yubin Y Fassbender Elizabeth S ES Shen Siyuan S Aranda Jorge J Kotagiri Namrata N Maker Michael M Liao Sha-Mei SM Jaffee Bruce D BD Poor Stephen H SH
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20180901 7
<h4>Purpose</h4>Mononuclear phagocytes (MNPs) are present in neovascular age-related macular degeneration (nv AMD) which is also called choroidal neovascularization (CNV). The number and phenotype of the MNPs depend upon the local environment in the CNV and effect of nv AMD therapy. We investigated ocular cell infiltration and conditions that modulate angiogenesis in a laser-induced mouse CNV model.<h4>Methods</h4>We developed assays to quantify MNPs in our established mouse CNV model. One MNP a ...[more]