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Cs?CO?-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers.

ABSTRACT: It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.

SUBMITTER: Dong C

PROVIDER: S-EPMC6154635 | biostudies-other | 2017 May

REPOSITORIES: biostudies-other

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Cs₂CO₃-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers.

Dong Cheng C Bai Xing-Feng XF Lv Ji-Yuan JY Cui Yu-Ming YM Cao Jian J Zheng Zhan-Jiang ZJ Xu Li-Wen LW

Molecules (Basel, Switzerland) 20170518 5

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones. ...[more]

PMID: 28524100

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