Ontology highlight
ABSTRACT:
SUBMITTER: Lai M
PROVIDER: S-EPMC6168901 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Lai Marta M Lanz Bernard B Poitry-Yamate Carole C Romero Jackeline F JF Berset Corina M CM Cudalbu Cristina C Gruetter Rolf R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20171019 10
In vivo <sup>13</sup>C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing <sup>13</sup>C-labeled glucose. Metabolic flux analysis of <sup>13</sup>C turnover previously yielded quantitative information of glutamate and glutamine metabolism in humans and rats, while the application to in vivo mouse brain remains exceedingly challenging. In the present study, <sup>13</sup>C direct detection at 14.1 T provided highly resolved i ...[more]