Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC6192028 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Organic letters 20180905 18
A general method for the enantioselective synthesis of carbo- and heterocyclic carbonyl compounds bearing fluorinated α-tetrasubstituted stereocenters using palladium-catalyzed decarboxylative allylic alkylation is described. The stereoselective C<sub>sp<sup>3</sup></sub>-C<sub>sp<sup>3</sup></sub> cross-coupling reaction delivers five- and six-membered ketone and lactam products bearing (poly)fluorinated tetrasubstituted chiral centers in high yields and enantioselectivities. These fluorinated, ...[more]