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Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function.

ABSTRACT: The association between anthropometric indices with chronic kidney disease (CKD) was examined previously. However, the effect of body fat on renal function was not determined clearly. Our aim was to investigate the association of percent body fat (PBF) and renal function in adult population from health examination in Tri-Service General Hospital (2010-2016). 35087 participants aged 20 years and older were enrolled in the study. PBF was measured by bioelectrical impedance analysis (BIA). Estimation of renal function was performed by Taiwanese MDRD equation. Optimal cut-off values of PBF was accessed by a receiver-operator characteristic (ROC) curve analysis. Multivariate regression models were used in the relationship among changes of PBF, renal function, and future CKD. In terms of baseline PBF for CKD, optimal cut-off values of PBF in males and females were 21.55 and 40.75. The changes of PBF were more closely associated with renal function decline than waist circumference (WC) with ? values of -0.173 (95% CI: -0.233, -0.112) and -0.077 (95% CI: -0.104, -0.049), respectively. After stratified by gender, this relationship remained significant in male population with ? values of -0.276 (95% CI: -0.371, -0.181) and -0.159 (95% CI: -0.207, -0.112), respectively. Female subjects with increased baseline PBF over cut-off values had increased risk for predicting the future CKD with odd ratios (ORs) of 2.298 (95% CI: 1.006-5.252). Body fat had detrimental impact on renal function and development of CKD in adult population. Measurement of PBF for surveillance of renal function impairment was warranted.

SUBMITTER: Chen YY

PROVIDER: S-EPMC6251878 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other

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Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function.

Chen Yuan-Yuei YY Fang Wen-Hui WH Wang Chung-Ching CC Kao Tung-Wei TW Chang Yaw-Wen YW Yang Hui-Fang HF Wu Chen-Jung CJ Sun Yu-Shan YS Chen Wei-Liang WL

Scientific reports 20181123 1

The association between anthropometric indices with chronic kidney disease (CKD) was examined previously. However, the effect of body fat on renal function was not determined clearly. Our aim was to investigate the association of percent body fat (PBF) and renal function in adult population from health examination in Tri-Service General Hospital (2010-2016). 35087 participants aged 20 years and older were enrolled in the study. PBF was measured by bioelectrical impedance analysis (BIA). Estimati ...[more]

PMID: 30470784

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Project description:BackgroundAlthough high body mass index (BMI) is a risk factor of heart failure (HF), HF patients with a higher BMI had a lower mortality rate than that in HF patients with normal or lower BMI, a phenomenon that has been termed the "obesity paradox". However, the relationship between body composition, i.e., fat or muscle mass, and clinical outcome in HF remains unclear.MethodsWe retrospectively analyzed data for 198 consecutive HF patients (76?years of age; males, 49%). Patients who were admitted to our institute for diagnosis and management of HF and received a dual-energy X-ray absorptiometry scan were included regardless of left ventricular ejection fraction (LVEF) categories. Muscle wasting was defined as appendicular skeletal muscle mass index <?7.0?kg/m2 in males and?<?5.4?kg/m2 in females. Increased percent body fat mass (increased FM) was defined as percent body fat >?25% in males and?>?30% in females.ResultsThe median age of the patients was 76?years (interquartile range [IQR], 67-82?years) and 49% of them were male. The median LVEF was 47% (IQR, 33-63%) and 33% of the patients had heart failure with reduced ejection fraction. Increased FM and muscle wasting were observed in 58 and 67% of the enrolled patients, respectively. During a 180-day follow-up period, 32 patients (16%) had cardiac events defined as cardiac death or readmission by worsening HF or arrhythmia. Kaplan-Meier survival curves showed that patients with increased FM had a lower cardiac event rate than did patients without increased FM (11.4% vs. 22.6%, p?=?0.03). Kaplan-Meier curves of cardiac event rates did not differ between patients with and those without muscle wasting (16.5% vs. 15.4%, p?=?0.93). In multivariate Cox regression analyses, increased FM was independently associated with lower cardiac event rates (hazard ratio: 0.45, 95% confidence interval: 0.22-0.93) after adjustment for age, sex, diabetes, muscle wasting, and renal function.ConclusionsHigh percent body fat mass is associated with lower risk of short-term cardiac events in HF patients.

Dataset Information

Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function.

Publications

Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function.

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