Ontology highlight
ABSTRACT:
SUBMITTER: Sirinimal HS
PROVIDER: S-EPMC6261332 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Sirinimal Hansamali S HS Hebert Sebastien P SP Samala Ganesh G Chen Heng H Rosenhauer Gregory J GJ Schlegel H Bernhard HB Stockdill Jennifer L JL
Organic letters 20180928 20
5- exo, 5- exo Cyclizations of conformationally unbiased propargylic aminyl radicals proceed with excellent yield, chemoselectivity, and diastereoselectivity under tin-free reductive cyclization conditions, regardless of the electronic environments and intermediate radical stabilization resulting from various olefin substituents. These conditions avoid the need for slow addition of initiator and reductant. By contrast, analogous 6- exo, 5- exo cyclizations require substituents capable of interme ...[more]