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A facile and mild synthesis of trisubstituted allylic sulfones from Morita-Baylis-Hillman carbonates.
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ABSTRACT:
SUBMITTER: Jiang L
PROVIDER: S-EPMC6272667 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Publications
A facile and mild synthesis of trisubstituted allylic sulfones from Morita-Baylis-Hillman carbonates.
Molecules (Basel, Switzerland) 20150507 5
An efficient and catalyst-free synthesis of trisubstituted allylic sulfones through an allylic sulfonylation reaction of Morita-Baylis-Hillman (MBH) carbonates with sodium sulfinates has been developed. Under the optimized reaction conditions, a series of trisubstituted allylic sulfones were rapidly prepared in good to excellent yields (71%-99%) with good to high selectivity (Z/E from 79:21 to >99:1). Compared with known synthetic methods, the current protocol features mild reaction temperature, ...[more]