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Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.

ABSTRACT: Some N-tosylhydrazone derivatives were effectively synthesized under solvent-free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup and easy purification of the target compounds were salient features of the present protocol, which enables straightforward access to N-tosylhydrazones. Among the tosylhydrazone derivatives evaluated, compound 3?l exhibits excellent apoptosis-promoting and anticancer potential against triple-negative breast cancer (TNBC) cell lines. This research shows that our synthesized compound 3?l may be a desirable and effective therapeutic drug against TNBC.

SUBMITTER: Xie Z

PROVIDER: S-EPMC6276103 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.

Xie Zengyang Z Song Yuying Y Xu Lujia L Guo Yukun Y Zhang Min M Li Limei L Chen Kai K Liu Xue X

ChemistryOpen 20181121 12

Some N-tosylhydrazone derivatives were effectively synthesized under solvent-free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup and easy purification of the target compounds were salient features of the present protocol, which enables straightforward access to N-tosylhydrazones. Among the tosylhydrazone derivatives evaluated, compound 3 l exhibits excellent apoptosis-promoting and anticancer pote ...[more]

PMID: 30524923

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