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Enhanced annihilation electrochemiluminescence by nanofluidic confinement.

ABSTRACT: Microfabricated nanofluidic electrochemical devices offer a highly controlled nanochannel geometry; they confine the volume of chemical reactions to the nanoscale and enable greatly amplified electrochemical detection. Here, the generation of stable light emission by electrochemiluminescence (ECL) in transparent nanofluidic devices is demonstrated for the first time by exploiting nanogap amplification. Through continuous oxidation and reduction of [Ru(bpy)3]2+ luminophores at electrodes positioned at opposite walls of a 100 nm nanochannel, we compare classic redox cycling and ECL annihilation. Enhanced ECL light emission of attomole luminophore quantities is evidenced under ambient conditions due to the spatial confinement in a 10 femtoliter volume, resulting in a short diffusion timescale and highly efficient ECL reaction pathways at the nanoscale.

SUBMITTER: Al-Kutubi H

PROVIDER: S-EPMC6301198 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Enhanced annihilation electrochemiluminescence by nanofluidic confinement.

Al-Kutubi Hanan H Voci Silvia S Rassaei Liza L Sojic Neso N Mathwig Klaus K

Chemical science 20181001 48

Microfabricated nanofluidic electrochemical devices offer a highly controlled nanochannel geometry; they confine the volume of chemical reactions to the nanoscale and enable greatly amplified electrochemical detection. Here, the generation of stable light emission by electrochemiluminescence (ECL) in transparent nanofluidic devices is demonstrated for the first time by exploiting nanogap amplification. Through continuous oxidation and reduction of [Ru(bpy)<sub>3</sub>]<sup>2+</sup> luminophores ...[more]

PMID: 30647886

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