Ontology highlight
ABSTRACT:
SUBMITTER: Britto DD
PROVIDER: S-EPMC6307908 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Britto Denver D DD Wyroba Barbara B Chen Wenxuan W Lockwood Rhoswen A RA Tran Khanh B KB Shepherd Peter R PR Hall Christopher J CJ Crosier Kathryn E KE Crosier Philip S PS Astin Jonathan W JW
Disease models & mechanisms 20181129 12
Tumour angiogenesis has long been a focus of anti-cancer therapy; however, anti-angiogenic cancer treatment strategies have had limited clinical success. Tumour-associated myeloid cells are believed to play a role in the resistance of cancer towards anti-angiogenesis therapy, but the mechanisms by which they do this are unclear. An embryonic zebrafish xenograft model has been developed to investigate the mechanisms of tumour angiogenesis and as an assay to screen anti-angiogenic compounds. In th ...[more]