Ontology highlight
ABSTRACT:
SUBMITTER: Khoza TA
PROVIDER: S-EPMC6331898 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Khoza Tebogo Ankie TA Makhafola Tshepiso Jan TJ Mphahlele Malose Jack MJ
Molecules (Basel, Switzerland) 20151215 12
Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3-dihydro-2H-imidazo[1,2-c]quinazolines. The latter were, in turn, subjected to sequential (Sonogashira and Suzuki-Miyaura) and one-pot two-step (Sonogashira/Stille) cross-coupling reactions to afford diversely functionalized polycarbo-substituted 2 ...[more]