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Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa.

ABSTRACT: A detailed chemical investigation of two South China Sea nudibranchs Phyllidiella pustulosa and Phyllidia coelestis, as well as their possible sponge-prey Acanthella cavernosa, led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid xidaoisocyanate A (1), one new naturally occurring nitrogen-containing kalihinane-type diterpenoid bisformamidokalihinol A (16), along with 17 known nitrogenous terpenoids (2?15, 17?19). The structures of all the isolates were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported axiriabiline A (5) was determined by X-ray diffraction (XRD) analysis. In a bioassay, the bisabolane-type sesquiterpenoids 8, 10, and 11 exhibited cytotoxicity against several human cancer cell lines.

SUBMITTER: Wu Q 

PROVIDER: S-EPMC6356796 | biostudies-other | 2019 Jan

REPOSITORIES: biostudies-other

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Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs <i>Phyllidiella pustulosa</i>, <i>Phyllidia coelestis</i>, and Their Sponge-Prey <i>Acanthella cavernosa</i>.

Wu Qihao Q   Chen Wen-Ting WT   Li Song-Wei SW   Ye Jian-Yu JY   Huan Xia-Juan XJ   Gavagnin Margherita M   Yao Li-Gong LG   Wang Hong H   Miao Ze-Hong ZH   Li Xu-Wen XW   Guo Yue-Wei YW  

Marine drugs 20190116 1

A detailed chemical investigation of two South China Sea nudibranchs <i>Phyllidiella pustulosa</i> and <i>Phyllidia coelestis</i>, as well as their possible sponge-prey <i>Acanthella cavernosa</i>, led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid xidaoisocyanate A (<b>1</b>), one new naturally occurring nitrogen-containing kalihinane-type diterpenoid bisformamidokalihinol A (<b>16</b>), along with 17 known nitrogenous terpenoids (<b>2</b>⁻<b>15</b>, <b>17</b>⁻<b>19</b>).  ...[more]

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