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Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1.

ABSTRACT: Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 ± 0.35 ?M, 25.6 ± 0.47 ?M, and 41.7 ± 0.71 ?M, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 ± 0.21 ?M and 26.7 ± 1.1 ?M, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against ?-glycosidase, with IC50 values of 78.2 ± 2.1 ?M and 49.3 ± 10.6 ?M, respectively.

SUBMITTER: Wang P

PROVIDER: S-EPMC6356855 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1.

Wang Pei P Cui Yan Y Cai Caihong C Chen Huiqin H Dai Yu Y Chen Pengwei P Kong Fandong F Yuan Jingzhe J Song Xinming X Mei Wenli W Dai Haofu H

Marine drugs 20181220 1

Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 ...[more]

PMID: 30577517

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