Ontology highlight
ABSTRACT:
SUBMITTER: Park YJ
PROVIDER: S-EPMC6386675 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Park Young-Jun YJ Ryu Heeju H Choi Garam G Kim Byung-Seok BS Hwang Eun Sook ES Kim Hun Sik HS Chung Yeonseok Y
Proceedings of the National Academy of Sciences of the United States of America 20190204 8
Expression of ectonucleotidase CD39 contributes to the suppressive activity of Foxp3<sup>+</sup> regulatory T cells (Tregs) by hydrolyzing immunogenic ATP into AMP. The molecular mechanism that drives CD39 expression on Tregs remains elusive. We found that tumor-infiltrating Tregs (Ti-Tregs) failed to up-regulate CD39 in mice lacking EBI3 subunit of IL-27 or IL-27Ra. Mixed bone marrow chimera and in vitro studies showed that IL-27 signaling in Tregs directly drives CD39 expression on Ti-Tregs in ...[more]