Ontology highlight
ABSTRACT:
SUBMITTER: Qu A
PROVIDER: S-EPMC6397542 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Qu Aihua A Sun Maozhong M Xu Liguang L Hao Changlong C Wu Xiaoling X Xu Chuanlai C Kotov Nicholas A NA Kuang Hua H
Proceedings of the National Academy of Sciences of the United States of America 20190211 9
Multiplexed detection of small noncoding RNAs responsible for posttranscriptional regulation of gene expression, known as miRNAs, is essential for understanding and controlling cell development. However, the lifetimes of miRNAs are short and their concentrations are low, which inhibits the development of miRNA-based methods, diagnostics, and treatment of many diseases. Here we show that DNA-bridged assemblies of gold nanorods with upconverting nanoparticles can simultaneously quantify two miRNA ...[more]