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Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)-H activation and C(sp3)-H amination.

ABSTRACT: A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)-H activation and C(sp3)-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.

SUBMITTER: Song L

PROVIDER: S-EPMC6404421 | biostudies-other | 2019

REPOSITORIES: biostudies-other

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Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)-H activation and C(sp3)-H amination.

Song Liangliang L Song Liangliang L Tian Guilong G Van der Eycken Johan J Van der Eycken Erik V EV

Beilstein journal of organic chemistry 20190227

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)-H activation and C(sp3)-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance. ...[more]

PMID: 30873242

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