Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Nunez E
PROVIDER: S-EPMC6517886 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Martín-Núñez Ernesto E Donate-Correa Javier J Kannengiesser Caroline C De Brauwere David-Paul DP Leroy Christine C Oudin Claire C Friedlander Gérard G Prieto-Morín Carol C Tagua Víctor G VG Ureña-Torres Pablo A PA Navarro-González Juan F JF
Journal of clinical medicine 20190412 4
Hyperphosphatemia is commonly present in end-stage renal disease. Klotho (KL) is implicated in phosphate homeostasis since it acts as obligate co-receptor for the fibroblast growth factor 23 (FGF23), a major phosphaturic hormone. We hypothesized that genetic variation in the KL gene might be associated with alterations in phosphate homeostasis resulting in hyperphosphatemia. We performed sequencing for determining <i>KL</i> gene variants in a group of resistant hyperphosphatemic dialysis patient ...[more]