Ontology highlight
ABSTRACT:
SUBMITTER: Shao W
PROVIDER: S-EPMC6555818 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Nature communications 20190607 1
Deterioration of biomolecules in clinical tissues is an inevitable pre-analytical process, which affects molecular measurements and thus potentially confounds conclusions from cohort analyses. Here, we investigate the degradation of mRNA and protein in 68 pairs of adjacent prostate tissue samples using RNA-Seq and SWATH mass spectrometry, respectively. To objectively quantify the extent of protein degradation, we develop a numerical score, the Proteome Integrity Number (PIN), that faithfully mea ...[more]