Dataset Information
Comparative analysis of mRNA degradation and protein degradation in prostate tissues indicates high stability of proteins
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Hela Cell
DISEASE(S): Cervical Cancer
SUBMITTER: 
Wenguang Shao
LAB HEAD: Ruedi Aebersold
PROVIDER: PXD013622 | Pride | 2019-06-12
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ConvertTSVToTraML.TraML | Other | |||
| feature_alignment.tsv | Tabular | |||
| iprophet.pep.xml | Pepxml | |||
| library_degradation_E1811131209.prot.xml | Xml | |||
| xuep_J180828_SW_1.wiff | Wiff |
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Publications
Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins.
Nature communications 20190607 1
Deterioration of biomolecules in clinical tissues is an inevitable pre-analytical process, which affects molecular measurements and thus potentially confounds conclusions from cohort analyses. Here, we investigate the degradation of mRNA and protein in 68 pairs of adjacent prostate tissue samples using RNA-Seq and SWATH mass spectrometry, respectively. To objectively quantify the extent of protein degradation, we develop a numerical score, the Proteome Integrity Number (PIN), that faithfully mea ...[more]
