Ontology highlight
ABSTRACT:
SUBMITTER: Scherr M
PROVIDER: S-EPMC6756054 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Scherr Michaela M Kirchhoff Hanna H Battmer Karin K Wohlan Katharina K Lee Chun-Wei CW Ricke-Hoch Melanie M Erschow Sergej S Law Edward E Kloos Arnold A Heuser Michael M Ganser Arnold A Hilfiker-Kleiner Denise D Heidenreich Olaf O Eder Matthias M
Leukemia 20181213 6
BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option for suitable patients. We here characterize the curative potential of BH3-mimetics differentially targeting mitochondrial BCL2-family members using a combination therapy approach with dexamethasone and tyrosine kinase inhibitors targeting BCR-ABL. In BCR-ABL + ALL BH3-mimetics act by redistribution of mitochondrial activator BIM, which is s ...[more]