Ontology highlight
ABSTRACT:
SUBMITTER: Pu Y
PROVIDER: S-EPMC6756889 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Pu Yaoyu Y Chang Lijia L Qu Youge Y Wang Siming S Zhang Kai K Hashimoto Kenji K
Aging 20190903 17
Although the brain-gut axis appears to play a role in the pathogenesis of Parkinson's disease, the precise mechanisms underlying the actions of gut microbiota in this disease are unknown. This study was undertaken to investigate whether antibiotic-induced microbiome depletion affects dopaminergic neurotoxicity in the mouse brain after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP significantly decreased dopamine transporter (DAT) immunoreactivity in the striatum and ...[more]