Dataset Information

Integrated Genomic Analysis of Periampullary Tumors

ABSTRACT:

Adenocarcinomas arising in the complex environment of the ampulla of Vater constitute a histopathological heterogenous group, presumably originating from the different epithelial cellular constituents present at the site: pancreas, bile duct, and intestinal duodenum. These tumors have been described in many different ways: intra-ampullary, periampullary, intra-ampullary papillary-tubular neoplasm, ampullary-ductal, periampullary-duodenal, and ampullary-not otherwise specified. These varied classifications reflect the difficulty in classifying these tumors into specific groups. Only the tumors clearly localized in the bile duct or duodenum are identified as distal cholangiocarcinomas (CAC) or duodenal adenocarcinomas (DUOAC). The current classification is based on macroscopic features that may distinguish the epithelium of origin, microscopic features, clinicopathological criteria, histopathology and expression of differential markers. This classification is subjective and prone to inter-observer variability and significantly impacts on treatment selection and therapeutic development.

In order to define subtypes of periampullary cancer with clinical relevance, we performed whole exome sequencing and copy number analysis of 160 cancers arising in the periampullary region, 62 of these clearly arising from either the bile duct (n = 44), or the duodenum (n = 18) and 98 periampullary cancers (AMPAC) where the epithelium of origin could not be clearly defined.

PROVIDER: phs000895 | dbGaP |

SECONDARY ACCESSION(S): PRJNA280133PRJNA280134

REPOSITORIES: dbGaP

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Source:

			Action	DRS
	GapExchange_phs000895.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000895.PeriampullaryTumors.v1.p1.MULTI.pdf	Pdf
	manifest_phs000895.PeriampullaryTumors.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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Integrated Genomic Analysis of Periampullary Tumors

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