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A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer

ABSTRACT: Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining erlotinib and bevacizumab with combination chemotherapy may kill more tumor cells. This phase I trial is studying the side effects and best dose of erlotinib when given together with bevacizumab, fluorouracil, leucovorin, and oxaliplatin in treating patients with metastatic or locally advanced colorectal cancer.

DISEASE(S): Adenocarcinoma,Stage Ivb Colon Cancer,Signet Ring Adenocarcinoma Of The Rectum,Stage Iiia Rectal Cancer,Stage Iiib Rectal Cancer,Stage Iiib Colon Cancer,Recurrent Colon Cancer,Stage Iiic Colon Cancer,Rectal Neoplasms,Cystadenocarcinoma,Stage Iiic Rectal Cancer,Stage Iva Rectal Cancer,Signet Ring Adenocarcinoma Of The Colon,Stage Ivb Rectal Cancer,Adenocarcinoma, Mucinous,Mucinous Adenocarcinoma Of The Colon,Recurrent Rectal Cancer,Colonic Neoplasms,Stage Iva Colon Cancer,Stage Iiia Colon Cancer,Mucinous Adenocarcinoma Of The Rectum

PROVIDER: 2009225 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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