Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

ABSTRACT: This phase II trial studies how well temsirolimus and bevacizumab work in treating patients with advanced endometrial, ovarian, liver, carcinoid, or islet cell cancer. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of cancer by blocking blood flow to the tumor. Giving temsirolimus together with bevacizumab may kill more tumor cells.

DISEASE(S): Ovarian Serous Surface Papillary Adenocarcinoma,Adenocarcinoma,Carcinoma,Ovarian Seromucinous Carcinoma,Stage Iv Primary Peritoneal Cancer,Stage Iiic Ovarian Cancer,Recurrent Primary Peritoneal Carcinoma,Regional Digestive System Neuroendocrine Tumor G1,Advanced Adult Hepatocellular Carcinoma,Lung Carcinoid Tumor,Fallopian Tube Neoplasms,Metastatic Digestive System Neuroendocrine Tumor G1,Pancreatic G-cell Adenoma,Stomach Neoplasms,Uterine Carcinosarcoma,Recurrent Fallopian Tube Carcinoma,Carcinoid Tumor,Malignant Pancreatic Insulinoma,Stage Iiic Primary Peritoneal Cancer,Stage Iiic Fallopian Tube Cancer,Stage Iv Fallopian Tube Cancer,Recurrent Digestive System Neuroendocrine Tumor G1,Stage Iiia Uterine Corpus Cancer,Mixed Tumor, Mullerian,Gastrinoma,Somatostatinoma,Stage Iva Uterine Corpus Cancer,Pancreatic Beta Cell Adenoma,Ovarian Endometrioid Adenocarcinoma,Stage Iiib Primary Peritoneal Cancer,Carcinoma, Hepatocellular,Carcinoma, Endometrioid,Intestinal Neoplasms,Ovarian Carcinosarcoma,Neuroendocrine Tumors,Stage Ivb Uterine Corpus Cancer,Stage Iiia Primary Peritoneal Cancer,Gastrointestinal Neoplasms,Stage Iiic Uterine Corpus Cancer,Insulinoma,Stage Iiia Fallopian Tube Cancer,Recurrent Adult Liver Carcinoma,Malignant Pancreatic Glucagonoma,Adenoma,Liver Neoplasms,Malignant Carcinoid Syndrome,Stage Iv Ovarian Cancer,Recurrent Pancreatic Neuroendocrine Carcinoma,Localized Non-resectable Adult Liver Carcinoma,Recurrent Ovarian Carcinoma,Stage Iiib Fallopian Tube Cancer,Ovarian Neoplasms,Cystadenocarcinoma, Serous,Stage Iiib Uterine Corpus Cancer,Pancreatic Neoplasms,Adenocarcinoma, Papillary,Stage Iiib Ovarian Cancer,Malignant Pancreatic Gastrinoma,Adult Hepatocellular Carcinoma,Pancreatic Alpha Cell Adenoma,Endometrial Serous Adenocarcinoma,Pancreatic Polypeptide Tumor,Carcinosarcoma,Stage Iiia Ovarian Cancer,Peritoneal Neoplasms,Carcinoma, Neuroendocrine,Recurrent Uterine Corpus Carcinoma,Malignant Pancreatic Somatostatinoma,Carcinoma, Ovarian Epithelial,Glucagonoma,Carcinoma, Islet Cell,Pancreatic Delta Cell Adenoma

PROVIDER: 2080521 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR