Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

ABSTRACT: This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with cetuximab and to see how well they work in treating patients with advanced gastrointestinal cancer, head and neck cancer, non-small cell lung cancer, or colorectal cancer. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Erlotinib hydrochloride and cetuximab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving erlotinib hydrochloride together with cetuximab may kill more tumor cells.

DISEASE(S): Recurrent Gallbladder Cancer,Adenocarcinoma,Stage Iv Colon Cancer,Granuloma,Stage Iv Rectal Cancer,Head And Neck Neoplasms,Recurrent Small Intestine Cancer,Recurrent Colon Cancer,Recurrent Extrahepatic Bile Duct Cancer,Recurrent Rectal Cancer,Stomach Neoplasms,Stage Iv Inverted Papilloma Of The Paranasal Sinus And Nasal Cavity,Recurrent Lymphoepithelioma Of The Oropharynx,Salivary Gland Neoplasms,Recurrent Gastric Cancer,Stage Iv Squamous Cell Carcinoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Esthesioneuroblastoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Verrucous Carcinoma Of The Oral Cavity,Squamous Cell Carcinoma Of Head And Neck,Rectal Neoplasms,Leiomyosarcoma,Mucoepidermoid Tumor,Advanced Adult Primary Liver Cancer,Stage Iv Basal Cell Carcinoma Of The Lip,Recurrent Gastrointestinal Carcinoid Tumor,Oropharyngeal Neoplasms,Stage Iv Squamous Cell Carcinoma Of The Hypopharynx,Recurrent Pancreatic Cancer,Gastrointestinal Neoplasms,Adenocarcinoma Of The Rectum,Recurrent Inverted Papilloma Of The Paranasal Sinus And Nasal Cavity,Liver Neoplasms,Recurrent Squamous Cell Carcinoma Of The Oropharynx,Lung Neoplasms,Small Intestine Leiomyosarcoma,Stage Iv Squamous Cell Carcinoma Of The Nasopharynx,Recurrent Esthesioneuroblastoma Of The Paranasal Sinus And Nasal Cavity,Recurrent Lymphoepithelioma Of The Nasopharynx,Carcinoma, Mucoepidermoid,Recurrent Adult Primary Liver Cancer,Metastatic Gastrointestinal Carcinoid Tumor,Stage Iv Squamous Cell Carcinoma Of The Lip And Oral Cavity,Neoplasms, Unknown Primary,Stage Iv Squamous Cell Carcinoma Of The Larynx,Carcinoma, Adenoid Cystic,Gastrointestinal Stromal Tumor,Recurrent Squamous Cell Carcinoma Of The Nasopharynx,Recurrent Esophageal Cancer,Unresectable Gallbladder Cancer,Gallbladder Neoplasms,Bile Duct Neoplasms,Recurrent Midline Lethal Granuloma Of The Paranasal Sinus And Nasal Cavity,Carcinoma, Verrucous,Gastrointestinal Stromal Tumors,Stage Iv Midline Lethal Granuloma Of The Paranasal Sinus And Nasal Cavity,Carcinoma,Tongue Cancer,Recurrent Squamous Cell Carcinoma Of The Hypopharynx,Recurrent Anal Cancer,Recurrent Salivary Gland Cancer,Recurrent Squamous Cell Carcinoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Lymphoepithelioma Of The Oropharynx,Recurrent Mucoepidermoid Carcinoma Of The Oral Cavity,Small Intestine Lymphoma,Stage Iv Lymphoepithelioma Of The Nasopharynx,Esophageal Neoplasms,Esthesioneuroblastoma, Olfactory,Recurrent Metastatic Squamous Neck Cancer With Occult Primary,Unresectable Extrahepatic Bile Duct Cancer,Nasopharyngeal Carcinoma,Carcinoid Tumor,Laryngeal Neoplasms,Stage Iv Gastric Cancer,Carcinoma Of The Appendix,Recurrent Squamous Cell Carcinoma Of The Lip And Oral Cavity,Small Intestine Adenocarcinoma,Recurrent Adenoid Cystic Carcinoma Of The Oral Cavity,Carcinoma, Squamous Cell,Tongue Neoplasms,Stage Iv Squamous Cell Carcinoma Of The Oropharynx,Intestinal Neoplasms,Recurrent Basal Cell Carcinoma Of The Lip,Carcinoma, Basal Cell,Recurrent Non-small Cell Lung Cancer,Stage Iv Mucoepidermoid Carcinoma Of The Oral Cavity,Malignant Carcinoid Syndrome,Paranasal Sinus Neoplasms,Stage Iv Esophageal Cancer,Adenocarcinoma Of The Colon,Carcinoma, Non-small-cell Lung,Papilloma, Inverted,Recurrent Verrucous Carcinoma Of The Oral Cavity,Pancreatic Neoplasms,Cholangiocarcinoma,Stage Iv Salivary Gland Cancer,Stage Iv Anal Cancer,Laryngeal Diseases,Recurrent Verrucous Carcinoma Of The Larynx,Stage Iv Pancreatic Cancer,Anus Neoplasms,Stage Iv Non-small Cell Lung Cancer,Stage Iv Adenoid Cystic Carcinoma Of The Oral Cavity,Stage Iv Verrucous Carcinoma Of The Larynx,Papilloma,Metastatic Squamous Neck Cancer With Occult Primary,Recurrent Squamous Cell Carcinoma Of The Larynx,Colonic Neoplasms

PROVIDER: 2034272 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR