Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

ABSTRACT: This phase II trial is studying the side effects and best dose of alemtuzumab when given together with fludarabine phosphate and total-body irradiation followed by cyclosporine and mycophenolate mofetil in treating patients who are undergoing a donor stem cell transplant for hematologic cancer. Giving low doses of chemotherapy, such as fludarabine phosphate, a monoclonal antibody, such as alemtuzumab, and radiation therapy before a donor stem cell transplant helps stop the growth of cancer cells. Giving chemotherapy or radiation therapy before or after transplant also stops the patient’s immune system from rejecting the donor’s bone marrow stem cells. The donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body’s normal cells. Giving cyclosporine and mycophenolate mofetil after the transplant may stop this from happening.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Lymphoma, Large-cell, Immunoblastic,Recurrent Childhood Anaplastic Large Cell Lymphoma,Childhood Burkitt Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Myelodysplastic/myeloproliferative Neoplasm, Unclassifiable,Leukemia, Hairy Cell,Childhood Immunoblastic Large Cell Lymphoma,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Previously Treated Myelodysplastic Syndromes,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,Leukemia, Myelomonocytic, Acute,Lymphoma, T-cell, Peripheral,Preleukemia,Lymphoma, B-cell, Marginal Zone,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Nodal Marginal Zone B-cell Lymphoma,Childhood Diffuse Large Cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Lymphoma, T-cell, Cutaneous,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Recurrent Mantle Cell Lymphoma,Relapsing Chronic Myelogenous Leukemia,Chronic Phase Chronic Myelogenous Leukemia,Recurrent Childhood Acute Lymphoblastic Leukemia,Childhood Chronic Myelogenous Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Leukemia, Myeloid, Acute,Leukemia, Myelomonocytic, Chronic,Testicular Lymphoma,Atypical Chronic Myeloid Leukemia, Bcr-abl1 Negative,Lymphoma, T-cell,Myelodysplastic Syndromes,Leukemia, Myelomonocytic, Juvenile,Recurrent Adult Acute Myeloid Leukemia,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Refractory Multiple Myeloma,Leukemia, Myeloid, Chronic, Atypical, Bcr-abl Negative,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Childhood Acute Lymphoblastic Leukemia In Remission,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Myeloproliferative Disorders,Myelodysplastic-myeloproliferative Diseases,Leukemia, Myeloid, Chronic-phase,Small Intestine Lymphoma,Refractory Hairy Cell Leukemia,Childhood Acute Myeloid Leukemia In Remission,Sezary Syndrome,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Adult Acute Myeloid Leukemia In Remission,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Childhood Acute Myeloid Leukemia,Multiple Myeloma,Juvenile Myelomonocytic Leukemia,Leukemia, Mast-cell,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Burkitt Lymphoma,Chronic Myelomonocytic Leukemia,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Acute Undifferentiated Leukemia,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Recurrent Grade 3 Follicular Lymphoma,Adult Acute Lymphoblastic Leukemia In Remission,Waldenström Macroglobulinemia,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Noncutaneous Extranodal Lymphoma,Angioimmunoblastic T-cell Lymphoma,Lymphoma, Large-cell, Anaplastic,Hepatosplenic T-cell Lymphoma,Secondary Myelodysplastic Syndromes,Leukemia, Lymphoid,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Anaplastic Large Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Peripheral T-cell Lymphoma,Mast Cell Leukemia,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2013367 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR