Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies

ABSTRACT: This clinical trial studies fludarabine phosphate and total-body radiation followed by donor peripheral blood stem cell transplant and immunosuppression in treating patients with hematologic malignancies. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient’s immune system from rejecting the donor’s stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient’s bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body’s normal cells. Giving total-body irradiation together with fludarabine phosphate, cyclosporine, and mycophenolate mofetil before transplant may stop this from happening.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Recurrent Childhood Anaplastic Large Cell Lymphoma,Neoplasms,Childhood Burkitt Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Myelodysplastic/myeloproliferative Neoplasm, Unclassifiable,Leukemia, Hairy Cell,Childhood Immunoblastic Large Cell Lymphoma,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Previously Treated Myelodysplastic Syndromes,Immunoglobulin Light-chain Amyloidosis,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Leukemia, Myelomonocytic, Acute,Lymphomatoid Granulomatosis,De Novo Myelodysplastic Syndromes,Lymphoma, T-cell, Peripheral,Preleukemia,Lymphoma, B-cell, Marginal Zone,Nodal Marginal Zone B-cell Lymphoma,Childhood Diffuse Large Cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Adult Acute Myeloid Leukemia With Inv(16)(p13;q22),Lymphoma, T-cell, Cutaneous,Adult Acute Myeloid Leukemia With Del(5q),Waldenstrom Macroglobulinemia,Lymphoma, Follicular,Acute Myeloid Leukemia/transient Myeloproliferative Disorder,Recurrent Mantle Cell Lymphoma,Recurrent Childhood Acute Lymphoblastic Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Leukemia, Myeloid, Acute,Leukemia, Myelomonocytic, Chronic,Stage Ii Multiple Myeloma,Leukemia, Large Granular Lymphocytic,Testicular Lymphoma,Untreated Adult Acute Myeloid Leukemia,Lymphoma, T-cell,Myelodysplastic Syndromes,Leukemia, Myelomonocytic, Juvenile,Recurrent Adult Acute Myeloid Leukemia,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Stage Iii Multiple Myeloma,Untreated Childhood Acute Lymphoblastic Leukemia,Refractory Multiple Myeloma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Childhood Acute Lymphoblastic Leukemia In Remission,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Myeloproliferative Disorders,Myelodysplastic-myeloproliferative Diseases,Small Intestine Lymphoma,Refractory Hairy Cell Leukemia,Childhood Acute Myeloid Leukemia In Remission,Sezary Syndrome,T-cell Large Granular Lymphocyte Leukemia,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Untreated Adult Acute Lymphoblastic Leukemia,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Adult Acute Myeloid Leukemia In Remission,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Childhood Acute Myeloid Leukemia,Multiple Myeloma,Juvenile Myelomonocytic Leukemia,Leukemia, Mast-cell,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Burkitt Lymphoma,Untreated Childhood Acute Myeloid Leukemia And Other Myeloid Malignancies,Chronic Myelomonocytic Leukemia,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Acute Undifferentiated Leukemia,Post-transplant Lymphoproliferative Disorder,Adult Acute Myeloid Leukemia With T(8;21)(q22;q22),Adult Acute Myeloid Leukemia With 11q23 (mll) Abnormalities,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Neoplasms, Plasma Cell,Recurrent Grade 3 Follicular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Adult Acute Lymphoblastic Leukemia In Remission,Waldenström Macroglobulinemia,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Noncutaneous Extranodal Lymphoma,Angioimmunoblastic T-cell Lymphoma,Blastic Plasmacytoid Dendritic Cell Neoplasm,Lymphoma, Large-cell, Anaplastic,Adult Acute Myeloid Leukemia With T(16;16)(p13;q22),Hepatosplenic T-cell Lymphoma,Leukemia, Lymphoid,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Anaplastic Large Cell Lymphoma,Primary Systemic Amyloidosis,Recurrent Grade 2 Follicular Lymphoma,Adult Acute Myeloid Leukemia With T(15;17)(q22;q12),Peripheral T-cell Lymphoma,Amyloidosis,Mast Cell Leukemia,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2006050 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR