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A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer

ABSTRACT: The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose and schedule of SRA737; and to evaluate the efficacy of SRA737 in prospectively-selected subjects with genetically-defined tumors that harbor genomic alterations linked to increased replication stress and that are hypothesized to be more sensitive to checkpoint kinase 1 (Chk1) inhibition via synthetic lethality. Specific cancer indications that frequently harbor these genetic mutations will be studied.

DISEASE(S): Advanced Solid Tumors,Advanced Solid Tumors Or Non-hodgkin's Lymphoma (nhl),Lymphoma, Non-hodgkin

PROVIDER: 2217119 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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