Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Higher intelligence is genetically linked with longevity

ABSTRACT: Higher intelligence is genetically linked with longevity

PROVIDER: PRJNA819011 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Higher intelligence is genetically linked with longevity

Project description:We report the application of mRNA sequencing technology for identifying that the genetic linkage of higher intelligence with longevity in Drosophilla melanogaster. a transcriptome analysis was performed by sequencing the total mRNA. The differentially expressed gene analysis by a negative binomial test showed that a subset of genes displayed remarkably altered expression where 56, 152, and 26 genes were significantly upregulated (adjusted P value <0.01), and 30, 397, and 10 genes were downregulated (adjusted P value < 0.01) in INT compared to F0, NINT compared to F0, and INT compared to NINT each. The functions of the differentially expressed genes were analyzed at high levels by using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment program. Compared to F0, the pathways of ribosome and autophagy were up-regulated in INT while the pathways related to metabolisms were down-regulated. Meanwhile, the pathways associated with genome stability and immune reaction was upregulated and the pathway of oxidative phosphorylation responsible for ATP generation was down regulated in NINT. The KEGG comparison of INT with NINT, which eliminates genes associated with the environmental factors during the selection process, visualized more precise pathways associated with higher intelligence and longevity. The pathways related to genome stability (Fanconi anemia pathway, Mismatch repair, DNA replication, Homologous recombination, and Nucleotide excision repair) and immune reaction (Toll and lmd signaling pathway) were up-regulated in NINT, and these pathways were down-regulated in INT.

2023-02-17 | GSE196981 | GEO

A cohesin traffic pattern genetically linked to gene regulation

Project description:A cohesin traffic pattern genetically linked to gene regulation

| PRJNA749181 | ENA

Circadian-affected tissue specificity is linked to aging and longevity

Project description:Circadian-affected tissue specificity is linked to aging and longevity

| PRJNA1004620 | ENA

Circadian-affected tissue specificity is linked to aging and longevity [sleep deprivation experiment]

Project description:Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated by the circadian clock. However, the distinction between circadian-affected tissue specificity and other tissue specificities remains poorly understood. Here, using multi-omics data on circadian rhythms in mice, we discovered that approximately 35% of tissue-specific genes are directly affected by circadian regulation. These circadian-affected tissue-specific genes have higher expression levels and are associated with metabolism and hepatocyte cells. They also exhibit specific features in long-reads sequencing data. Notably, these genes are associated with aging and longevity at both the gene level and at the network module level. The expression of these genes oscillates in response to caloric and time-restricted feeding regimens, which have been demonstrated to promote longevity. In addition, aging and longevity genes are disrupted in various circadian disorders. Our study indicates that the modulation of circadian-affected tissue specificity is essential for understanding the circadian mechanisms that regulate aging and longevity at the genomic level.

2024-06-03 | GSE240689 | GEO

Retinoic acid modulation of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.

Project description:Retinoic acid modulation of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.

| PRJNA1137311 | ENA

A cohesin traffic pattern genetically linked to gene regulation [Hi-C]

Project description:A cohesin traffic pattern genetically linked to gene regulation [Hi-C]

| PRJNA750104 | ENA

A cohesin traffic pattern genetically linked to gene regulation [RNA-Seq]

Project description:A cohesin traffic pattern genetically linked to gene regulation [RNA-Seq]

| PRJNA749272 | ENA

A cohesin traffic pattern genetically linked to gene regulation [CRISPR screens]

Project description:A cohesin traffic pattern genetically linked to gene regulation [CRISPR screens]