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Increasing Uptake of Evidence-Based Screening Services Through CHW-led Multi-modality Intervention

ABSTRACT: The purpose of this research study is to determine the best way to increase screening for cervical cancer, colorectal cancer, HIV, and Hepatitis C among under screened Hispanic, Haitian and African-American individuals in Hialeah, South Dade, and Little Haiti. The investigator will compare home testing led by a community health worker (CHW) versus clinic testing guided by a CHW. Community Health Workers are people who have undergone several weeks of community outreach and health education training. During the study period the participant will continue to receive all of their regular medical care from their regular health care providers. If the participant does not have a health care provider, the Community Health Workers would be able to help in referring the participant for care at a local health care clinic located in their community.

DISEASE(S): Human Immunodeficiency Virus,Acquired Immunodeficiency Syndrome,Colorectal Cancer,Hiv Infections,Human Papillomavirus,Hepatitis C

PROVIDER: 2230323 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Phenotypic plasticity shapes genome architecture in the honeybee Apis mellifera (RNA-seq)

Project description:Female honeybees are specified as workers or queens based on diet during early development. Workers are essentially sterile with a reduced number of ovarioles and no spermatheca. In the presence of the queen (queen mandibular pheromone) and her brood, worker ovaries are kept in an inactive quiescent state. If the queen is removed, or lost, worker bees are able to sense this change in their environment and their ovaries undergo complete remodeling producing unfertilized haploid eggs that will produce male (drone bees). In this study we analyze gene expression in queen, worker, and laying worker ovaries using RNA-seq and explore differences in the chromatin landscape (focusing on H3K27me3).

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Phenotypic plasticity shapes genome architecture in the honeybee Apis mellifera (ChIP-seq)

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2019-09-17 | GSE120560 | GEO

A Study Of TeleGenetics Versus Usual Care To Increase Access To Cancer Genetic Services

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Transcription profiling of abdomens from wild type and anarchistic strains of worker honey bees to identify genes related to ovary activation

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Transcription profiling of genes related to ovary activation in worker honey bee brains

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cGMP modulates responses to queen mandibular pheromone in worker honey bees

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2011-06-15 | E-MEXP-3135 | biostudies-arrayexpress

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Small RNA expression and caste differentiation in the honeybee

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Transcription profiling of honey bee brain and ovary reveals pheromone response is correlated with reproductive traits and brain gene expression in individual honey bees

Project description:In honey bees (Apis mellifera), the reproductive queen produces a pheromonal signal that regulates many aspects of worker behavior and physiology and is critical for maintaining colony organization. Queen mandibular pheromone (QMP) inhibits worker reproduction, attracts workers from a short distance (retinue response), inhibits the rearing of new queens, modulates age-related division of labor and globally alters brain gene expression in worker bees. Interestingly, substantial variation in worker retinue responses to QMP has been found between colonies, but the molecular and physiological bases for variation in individual responses to the queen have not been characterized. Here, we demonstrate that individual retinue response is negatively correlated with traits associated with reproductive potential. Workers with low response to QMP have more ovarioles and higher levels of vitellogenin transcripts than workers with a high response to QMP, suggesting that workers with greater reproductive potential may be attempting to escape queen control. Retinue response appears to be associated with a suite of behavioral and physiological traits that may be pleiotropically linked. However, while these phenotypes are all correlated at the organismal level, the underlying brain expression patterns and gene networks associated with each trait are independent, suggesting that these phenotypes are uncoupled at the molecular level in adult bees. These studies provide insights into the ultimate and proximate causes of natural variation in pheromone response in honey bees.

2008-12-31 | E-MEXP-1724 | biostudies-arrayexpress

mRNA-Seq of brain tissue from honeybee (Apis mellifera) drones (male), workers (female) and queens (female).

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