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Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

ABSTRACT: This phase I trial studies the side effects and best dose of trametinib and trifluridine and tipiracil hydrochloride in treating patients with colon or rectal cancer that has spread to other places in the body (advanced/metastatic) or cannot be removed by surgery. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as trifluridine and tipiracil hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib and trifluridine and tipiracil hydrochloride may prevent cancer cells from dividing and work better in treating patients with colon and rectal cancer.

DISEASE(S): Stage Iva Colorectal Cancer Ajcc V7,Stage Ivb Rectal Cancer Ajcc V7,Carcinoma,Stage Iiib Colon Cancer Ajcc V7,Metastatic Colorectal Carcinoma,Stage Iv Rectal Cancer Ajcc V7,Stage Iii Colon Cancer Ajcc V7,Stage Iiic Rectal Cancer Ajcc V7,Metastatic Rectal Carcinoma,Stage Iiic Colorectal Cancer Ajcc V7,Stage Ivb Colorectal Cancer Ajcc V7,Stage Iv Colon Cancer Ajcc V7,Stage Iva Colon Cancer Ajcc V7,Colorectal Neoplasms,Stage Iiib Rectal Cancer Ajcc V7,Metastatic Colon Carcinoma,Stage Iiib Colorectal Cancer Ajcc V7,Stage Iiic Colon Cancer Ajcc V7,Stage Iv Colorectal Cancer Ajcc V7,Stage Iiia Colon Cancer Ajcc V7,Stage Iiia Rectal Cancer Ajcc V7,Stage Iiia Colorectal Cancer Ajcc V7,Ras Family Gene Mutation,Stage Ivb Colon Cancer Ajcc V7,Rectal Neoplasms,Stage Iva Rectal Cancer Ajcc V7,Stage Iii Rectal Cancer Ajcc V7,Stage Iii Colorectal Cancer Ajcc V7,Colonic Neoplasms

PROVIDER: 2256966 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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