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Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer

ABSTRACT: This phase IIa trial studies how well rintatolimod and pembrolizumab works in treating patients with colorectal cancer that does not respond to treatment (refractory), has spread to other places in the body (metastatic), or otherwise cannot be removed by surgery (unresectable). Rintatolimod is an immuno-oncology agent that can stimulate the immune system. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving rintatolimod and pembrolizumab together may work better than standard of care in treating patients with colorectal cancer.

DISEASE(S): Stage Ivc Colorectal Cancer Ajcc V8,Adenocarcinoma,Metastatic Colorectal Adenocarcinoma,Stage Iva Colorectal Cancer Ajcc V8,Unresectable Colorectal Carcinoma,Stage Iv Colorectal Cancer Ajcc V8,Stage Iiic Colorectal Cancer Ajcc V8,Stage Iiia Colorectal Cancer Ajcc V8,Stage Ivb Colorectal Cancer Ajcc V8,Colorectal Neoplasms,Microsatellite Stable,Stage Iii Colorectal Cancer Ajcc V8,Mismatch Repair Proficient,Refractory Colorectal Adenocarcinoma,Stage Iiib Colorectal Cancer Ajcc V8

PROVIDER: 2318603 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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